science

 

The Research & Development (R&D) Division at Amerimmune consists of a group of scientists committed to relating basic immunological science with symptoms and disease progression to better understand diseases and mechanisms with which to target when determining biomarkers for diagnosis or treatment options. The scientists of our R&D team are intimately familiar with the immunodeficiency within the community and desire to shed more light on them.  They also want to provide deeper insight to the physicians who treat them. Therefore, all the R&D projects and collaborations here at Amerimmune aim to not only bring more knowledge into the basic science field of immunology, but also to the translational field of immunology.

 

Publications from Amerimmune

 

Improved panels for clinical immune phenotyping: Utilization of the violet laser.

Ryherd M, Plassmeyer M, Alexander C, Eugenio I, Kleschenko Y, Badger A, Gupta R, Alpan O, Sønder SU.
Cytometry B Clin Cytom. 2017 May 10. doi: 10.1002/cyto.b.21532.

 

Peanut consumption in infants at risk for peanut allergy.

Noonan L, Alpan O.
N Engl J Med. 2015 May 28;372(22):2163. doi: 10.1056/NEJMc1504021. 

 

A pilot study of omalizumab in eosinophilic esophagitis.

Loizou D, Enav B, Komlodi-Pasztor E, Hider P, Kim-Chang J, Noonan L, Taber T, Kaushal S, Limgala R, Brown M, Gupta R, Balba N, Goker-Alpan O, Khojah A, Alpan O.
PLoS One. 2015 Mar 19;10(3):e0113483. doi: 10.1371/journal.pone.0113483. eCollection 2015.

 

 

High eosinophil count: a potential biomarker for assessing successful omalizumab treatment effects.

Busse W, Spector S, Rosén K, Wang Y, Alpan O.
J Allergy Clin Immunol. 2013 Aug;132(2):485-6.e11. doi: 10.1016/j.jaci.2013.02.032. Epub 2013 Apr 13. No abstract available.

 

Oral immunotherapy for egg allergy in children.

Alpan O, Miehlke S, Straumann A.
N Engl J Med. 2012 Oct 11;367(15):1472; author reply 1472-3. doi: 10.1056/NEJMc1209949. No abstract available

 

 

Publications from Collaborations

 

A 6-month, multicenter, open-label study of fixed dose naproxen/esomeprazole in adolescent patients with juvenile idiopathic arthritis.

Lovell DJ, Dare JA, Francis-Sedlak M, Ball J, LaMoreaux BD, Von Scheven E, Reinhardt A, Jerath R, Alpan O, Gupta R, Goldsmith D, Zeft A, Naddaf H, Gottlieb B, Jung L, Holt RJ.
Pediatr Rheumatol Online J. 2018 Jun 26;16(1):41. doi: 10.1186/s12969-018-0260-y.

 

 

Time of Initiating Enzyme Replacement Therapy Affects Immune Abnormalities and Disease Severity in Patients with Gaucher Disease.

Limgala RP, Ioanou C, Plassmeyer M, Ryherd M, Kozhaya L, Austin L, Abidoglu C, Unutmaz D, Alpan O, Goker-Alpan O.
PLoS One. 2016 Dec 12;11(12):e0168135. doi: 10.1371/journal.pone.0168135. eCollection 2016

 

Enzyme replacement therapy reverses B lymphocyte and dendritic cell dysregulations in patients with Gaucher Disease.

Limgala RP, Jani C, Ioanou C, Alpan O, Goker-Alpan O.
Blood Cells Mol Dis. 2018 Feb;68:81-85. doi: 10.1016/j.bcmd.2016.10.015. Epub 2016 Oct 28.

 

Persistent immune alterations and comorbidities in splenectomized patients with Gaucher disease.

Sønder SU, Limgala RP, Ivanova MM, Ioanou C, Plassmeyer M, Marti GE, Alpan O, Goker-Alpan O.
Blood Cells Mol Dis. 2016 Jul;59:8-15. doi: 10.1016/j.bcmd.2016.02.003. Epub 2016 Feb 15.

 

Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults With Eosinophilic Esophagitis.

Safroneeva E, Straumann A, Coslovsky M, Zwahlen M, Kuehni CE, Panczak R, Haas NA, Alexander JA, Dellon ES, Gonsalves N, Hirano I, Leung J, Bussmann C, Collins MH, Newbury RO, De Petris G, Smyrk TC, Woosley JT, Yan P, Yang GY, Romero Y, Katzka DA, Furuta GT, Gupta SK, Aceves SS, Chehade M, Spergel JM, Schoepfer AM; International Eosinophilic Esophagitis Activity Index Study Group.
Gastroenterology. 2016 Mar;150(3):581-590.e4. doi: 10.1053/j.gastro.2015.11.004. Epub 2015 Nov 14.

 

Eosinophilic oesophagitis: relationship of quality of life with clinical, endoscopic and histological activity.

Safroneeva E, Coslovsky M, Kuehni CE, Zwahlen M, Haas NA, Panczak R, Taft TH, Hirano I, Dellon ES, Gonsalves N, Leung J, Bussmann C, Woosley JT, Yan P, Romero Y, Furuta GT, Gupta SK, Aceves SS, Chehade M, Straumann A, Schoepfer AM; International EEsAI Study Group.
Aliment Pharmacol Ther. 2015 Oct;42(8):1000-10. doi: 10.1111/apt.13370. Epub 2015 Aug 14.

 

How do gastroenterologists assess overall activity of eosinophilic esophagitis in adult patients?

Schoepfer AM, Panczak R, Zwahlen M, Kuehni CE, Coslovsky M, Maurer E, Haas NA, Alexander JA, Dellon ES, Gonsalves N, Hirano I, Leung J, Bussmann C, Collins MH, Newbury RO, De Petris G, Smyrk TC, Woosley JT, Yan P, Yang GY, Romero Y, Katzka DA, Furuta GT, Gupta SK, Aceves SS, Chehade M, Blanchard C, Straumann A, Safroneeva E; International EEsAI Study Group.
Am J Gastroenterol. 2015 Mar;110(3):402-14. doi: 10.1038/ajg.2015.32. Epub 2015 Mar 3.

 

Efficacy and Safety of Omalizumab in Patients with Chronic Idiopathic/Spontaneous Urticaria who Remain Symptomatic on H1 Antihistamines: A Randomized, Placebo-Controlled Study.

Saini SS, Bindslev-Jensen C, Maurer M, Grob JJ, Bülbül Baskan E, Bradley MS, Canvin J, Rahmaoui A, Georgiou P, Alpan O, Spector S, Rosén K.
J Invest Dermatol. 2015 Mar;135(3):925. doi: 10.1038/jid.2014.512. Epub 2014 Dec 11

 

Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis.

Rothenberg ME, Wen T, Greenberg A, Alpan O, Enav B, Hirano I, Nadeau K, Kaiser S, Peters T, Perez A, Jones I, Arm JP, Strieter RM, Sabo R, Gunawardena KA.
J Allergy Clin Immunol. 2015 Feb;135(2):500-7. doi: 10.1016/j.jaci.2014.07.049. Epub 2014 Sep 13.

 

Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis.

Schoepfer AM, Straumann A, Panczak R, Coslovsky M, Kuehni CE, Maurer E, Haas NA, Romero Y, Hirano I, Alexander JA, Gonsalves N, Furuta GT, Dellon ES, Leung J, Collins MH, Bussmann C, Netzer P, Gupta SK, Aceves SS, Chehade M, Moawad FJ, Enders FT, Yost KJ, Taft TH, Kern E, Zwahlen M, Safroneeva E; International Eosinophilic Esophagitis Activity Index Study Group.
Gastroenterology. 2014 Dec;147(6):1255-66.e21. doi: 10.1053/j.gastro.2014.08.028. Epub 2014 Aug 23